M6 Case Study – PKU This case study introduces a college student with phenylketonuria (PKU), a fatal genetic disorder, which can be successfully managed by diet. You will use the Hardy-Weinberg Principle to analyze the population genetics of this mutation. You will learn how to estimate the number of carriers for PKU in the population and then how to estimate the probability of having a child with PKU. Click on the following link to view a case study about PKU: Case Study – PKU Carriers: How Many Are in Your Hometown? use this lin : https://sciencecases.lib.buffalo.edu/files/pku.pdf Download the Case Study Report Form, fill in the answers, and submit. M6 Case Study Report Form For assistance with issues such as library resources, citing sources, plagiarism, tutoring, writing assistance, etc., browse the links that appear when you click on the tabs across the top banner of the course page to find further information.Part I PKU1. What are Janes symptoms when she eats foods containing the amino acid phenylalanine?2. Given these symptoms, what organ is most affected when a person with PKU consumes the amino acid phenylalanine in their diet?3. A person without PKU does not have any symptoms when they consume foods with the amino acid phenylalanine. Why might Jane have the symptoms she does when she consumes foods with phenylalanine?4. What are the genotypes of Janes parents?5. What are the genotypes of Janes brother and sister?6. What is Janes genotype?Part II Hardy-Weinberg1. Who is correct? Can Jane and Amanda directly count the numbers of carriers in a population? Why or why not?2. Can Jane and Amanda determine any of the allele and/or genotype frequencies in the population just by counting? If so, which one(s)?Part III Carriers1. Once Jane and Amanda know the frequency of the homozygous recessive genotype (q2), how can they determine the frequency of the recessive allele (q)?2. How can Jane and Amanda determine the frequency of the dominant allele (p)?3. If 33 of the 300,000 people in Corpus Christi, TX, have PKU, how many people are carriers (heterozygous) for PKU?4. Dr. Jones mentioned that the allele and genotype frequencies in a population will not change over time if no evolutionary forces are acting on that population. To determine the number of carriers in a population, you make the assumption that no evolutionary forces are acting on the population. What are these evolutionary forces?5. Is their reasoning sound? Did they correctly calculate their chance of having a child with PKU? If not, what should they include in their calculations?6. If Jane marries somebody in Corpus Christi without symptoms of PKU, what is the chance that she and her husband will have a child with PKU?7. If Amanda marries somebody in Corpus Christi without symptoms of PKU, what is the chance that she and her husband will have a child with PKU?
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